President Bashar al-Assad has said he fears the country's present suffering through war funded by outsiders to overthrow him, could erupt into a full-scale global conflict.
He argued that US intervention to help the rebels, as well as the Russian backing of government forces, could lead to direct conflict between the superpowers.
President Assad warned the conflict had already gone beyond a 'Cold War' but said he hoped it would not escalate any further.
'I hope we don't see any direct conflict between these superpowers, because this is where things are going to be out of control for the rest of the world,' Assad said in the interview with Greek newspaper Kathimerini.
'It's something more than a cold war, but less than a full-blown war.'
The President also took the opportunity to praise his Russian backers - saying that if a world war was avoided it would be 'because of the wisdom of the Russians' rather than President Trump.
'Since Trump's campaign, the main agenda was against Russia, create a conflict with Russia, humiliate Russia, undermine Russia, and so on,' he added.
'Fortunately, you have a wise leadership in Russia, and they know that the agenda of the deep state in the United States is to create a conflict.'
Since Donald Trump's decision to back out of the Iran nuclear deal on Wednesday, there have been a number of skirmishes between rival Middle Eastern forces using Syria as a battleground.
Assad warned that the Western backing of Syrian factions has led to a complication of the civil war which could lead to the conflict spilling over into neighboring countries and dragging in more and more nations.
'The Turkish, French, whoever, they are all enemies; as long as they came to Syria illegally, they are our enemies,' Assad added.
'Forget about the different factions and who is going to finance those factions; at the end of the day, they work for one agenda, and those different players obey one master: the American master.'
On the question of chemical weapons, Assad said his country complied with UN Resolutions and handed over its stockpiles to international authorities.
"We don't have a chemical arsenal since we gave it up in 2013" sad Assad. The Organization for the Prohibition of Chemical Weapons (OPCW) made investigations about this, and it's clear that we don't have them.'
Last month, at least 49 people were killed and dozens more injured in an alleged chemical weapons attack. The US and other Western countries accused the Syrian regime of staging the assault.
But Assad refused to accept responsibility for the attack in rebel-held Douma, saying: 'It's a farce, it's a play. It's a very primitive play just to attack the Syrian army.'